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Alopecia

Understanding Alopecia: Types, Causes, and Treatment Approaches

Alopecia is the clinical term for hair loss and is a complex condition that affects millions of people worldwide.  To effectively manage alopecia, it’s essential to comprehend its various types, underlying causes, and available treatment approaches.

Discover the different forms of alopecia, from common patterns like androgenetic alopecia (male and female pattern baldness) to autoimmune conditions like alopecia areata. Explore the diverse causes, ranging from genetics and hormonal imbalances to stress and autoimmune responses.

Alopecia Areata (AA)

Alopecia Areata, also known as “Patchy Hair Loss,” is an autoimmune condition that can occur anywhere on the skin, but it is frequently observed on the scalp and beard areas. The name itself provides insight into the nature of the condition, where “Alopecia” means the loss of hair, and “Areata” refers to patches. These patches usually develop suddenly and are typically round or oval. One of the main characteristics of Alopecia Areata is the presence of “exclamation mark hairs.”

These are telogen hairs that are thicker at the ends than at the bulb end. There may also be a loss of pigment at the bulb end of the shaft. In some cases, these hairs may break at the scalp level, leaving a “black dot” in the follicles. The cause of Alopecia Areata is said to be the result of an autoimmune problem, where the body’s immune system mistakenly targets hair follicles. As inflammation increases, the immune privilege in the hair follicles collapses, leading to distinct patches. Various triggers can set off this autoimmune response, including viral or bacterial infections, vaccinations, stress, and trauma to the skin. Genetic disposition also plays a role in Alopecia Areata. 

Individuals with a family history of autoimmune problems, such as vitiligo, thyroid issues, rheumatoid arthritis, or pernicious anemia, may be more susceptible. Around 40% of individuals with Alopecia Areata also have atopic diseases like allergies and asthma.

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Alopecia Totalis (AT)

Alopecia Totalis is an extension of Alopecia Areata, representing a more advanced and extensive form of hair loss. While Alopecia Areata is characterized by hair loss in patches, Alopecia Totalis refers to the complete loss of hair on the scalp. This means the hair loss extends beyond distinct patches, involving all hair on the head. The condition results in a smooth, bald surface across the entire scalp.

Similar to Alopecia Areata, Alopecia Totalis is thought to be an autoimmune problem. The immune system mistakenly targets and attacks hair follicles, leading to the loss of hair. Triggers for this autoimmune response can also include viral or bacterial infections, vaccinations, stress, trauma to the skin, or exposure to substances that become antigens to the body.

Alopecia Universalis (AU)

Alopecia Universalis is another advanced form of Alopecia Areata, representing an extensive and severe form of hair loss. While Alopecia Areata is characterized by localized patches of hair loss, and Alopecia Totalis refers to complete scalp baldness, Alopecia Universalis takes it to an extreme level. In this condition, there is complete hair loss not only on the scalp but also across the entire body, including eyebrows, eyelashes, and body hair.

Alopecia Universalis results in a total absence of hair, presenting a distinctive and striking appearance. The underlying cause is also believed to be an autoimmune response where the immune system mistakenly targets hair follicles, leading to their disruption and subsequent hair loss. Like Alopecia Areata and Alopecia Totalis, triggers for Alopecia Universalis can include various factors such as viral or bacterial infections, vaccinations, stress, trauma to the skin, or exposure to substances that become antigens to the body.

Happy black woman with Alopecia that started to receive treatment with a Trichologist in Brampton

Types of Alopecia

Hormonal Hair Loss

Hormonal hair loss affects both men and women differently. In men, a common example is androgenetic alopecia (male pattern baldness). Hormonal changes, particularly the conversion of testosterone to dihydrotestosterone (DHT), contribute to hair loss. DHT affects hair follicles, leading to their miniaturization and eventual thinning of hair. Men often experience this hormonal hair loss with a predictable pattern, starting with a receding hairline and thinning at the crown.

For women, hormonal shifts during menopause or conditions like polycystic ovary syndrome (PCOS) can significantly impact the balance of testosterone and DHT. PCOS is a prevalent hormonal disorder in women, increasing androgen levels that can trigger hormonal hair loss. Unwanted facial hair and acne may accompany this condition.

Another common cause of hormonal hair loss is thyroid imbalances, disrupting the body’s endocrine system. Conditions like hypothyroidism or hyperthyroidism can induce changes in hair texture, density, and overall health. Hypothyroidism, characterized by an underactive thyroid, leads to dry, brittle hair prone to breakage. Hyperthyroidism, marked by an overactive thyroid, may cause excessive hair shedding. Management involves addressing the underlying thyroid condition through medication, lifestyle adjustments, and a nutrient-rich diet. These genetic and hormonal changes result in hair thinning, often distributed across the scalp.

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Traction Alopecia

Traction alopecia is a form of hair loss caused by prolonged tension or pulling on the hair. This condition commonly arises from certain hairstyles that exert constant stress on the hair follicles, such as tight ponytails, braids, or hair weaves. Over time, this persistent pulling damages the hair follicles, leading to hair thinning and, in severe cases, permanent hair loss. Traction alopecia is often avoidable by opting for hairstyles that don’t cause excessive strain on the hair, and early detection can improve the chances of reversible damage through lifestyle changes and proper care.

Telogen Effluvium

Telogen Effluvium is a type of temporary hair loss define by an increased shedding of hair during the resting (telogen) phase of the hair growth cycle. This condition is often triggered by significant physiological or emotional stressors, such as illness, surgery, childbirth, or severe emotional distress. The stressors disrupt the normal hair growth cycle, pushing a larger number of hair follicles into the telogen phase, leading to noticeable hair shedding.

Unlike some other forms of hair loss, Telogen Effluvium is generally reversible, and the hair usually can regrow once the underlying cause or stressor is addressed. Diagnosis often involves identifying the triggering event and ruling out other potential causes. While the condition can be distressing, understanding its temporary nature and addressing the root cause are key steps in managing telogen effluvium.

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Scarring Alopecia Conditions

Scarring Alopecia refers to a group of hair loss conditions where inflammation leads to irreversible damage and scarring of hair follicles. These conditions are often challenging to manage, requiring early diagnosis and intervention to minimize hair loss and reduce inflammation. Treatment approaches may involve topical or systemic approaches to control inflammation. Regular monitoring and a multidisciplinary approach involving a trichologists and sometimes medical professionals are crucial for effective management.

Among these conditions are several distinct entities:

CCCA – Central Centrifugal Cicatricial Alopecia:

This condition predominantly affects the central scalp, radiating outward from the crown and is most prevalent in women of black women. Hair loss occurs gradually with scarring, often with a sunken appearance on the scalp.

Lichen Planopilaris (LPP)

Lichen Planopilaris is an inflammation autoimmune condition leading to scarring and permanent hair loss. It is characterized by reddish-brown patches, perifollicular scaling, and loss of follicular openings. LPP commonly affects the scalp but may extend to other body hair.

Frontal Fibroising Alopecia (FFA)

Frontal Fibrosing Alopecia affects both men and women but mainly affects postmenopausal women at the frontal hairline recession, scarring, and loss of eyebrows. It follows a progressive and symmetrical pattern of hair loss.

Discoid Lupus Erythematosus (DLE)

Discoid Lupus Erythematosus is an autoimmune condition affecting the skin. It presents with circular lesions, erythema, and scaling, often leading to scarring. Common sites of involvement include the scalp, face, and ears.

Folliculitis Decalvans (FD)

Folliculitis Decalvans involves chronic inflammation around hair follicles, resulting in pustules, crusting, and eventual scarring. While primarily affecting the scalp, FD can extend to other body areas.